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Sathis Kumar, D.
- Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract
Abstract Views :235 |
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Authors
Affiliations
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 22-24Abstract
Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.Keywords
Wrightia tinctoria Roxb, Schrebera swietenoides Roxb, Maltase, Acarbose.
References
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- Inhibitory Effects of Ethanolic Extract of Physalis minima on Amylase, Lipase and Alpha Glucosidase
Abstract Views :168 |
PDF Views:0
Authors
S. N. Raju
1,
D. Sathis Kumar
2,
Otilia Banji
1,
David Banji
1,
P. Yogeswaran
1,
D. Narender Prasad
1,
A. Harani
1
Affiliations
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
2 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
2 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 159-162Abstract
The aim of the present study was to assess the effects of ethanolic extract of Physalis minima on the amylase, lipase and alpha glucosidase activity in vitro. Powder of whole plant of Physalis minima was extracted in ethanol and the extract was assayed for the measurement of inhibitory effects on activities of enzymes. The extracts rich in bioactive phytochemicals showed inhibitory activity on the amylase, lipase and alpha glucosidase, thus suggesting that extract might be useful in the treatment to limit dietary fat and glucose absorption and the accumulation of fat in adipose tissue. The extracts of Physalis minima may be safe, natural and cost effective for reducing fat and glucose absorption.Keywords
Physalis minima, Amylase, Lipase, Alpha Glucosidase.- Batch Biosorption Studies for the Removal of Chromium
Abstract Views :142 |
PDF Views:0
Authors
Affiliations
1 VMKV Engineering College, Salem, Tamilnadu, IN
2 Vikas College of Pharmacy, Suryapet, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
4 SASTRA University, Thanjavur, Tamilnadu, IN
1 VMKV Engineering College, Salem, Tamilnadu, IN
2 Vikas College of Pharmacy, Suryapet, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
4 SASTRA University, Thanjavur, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 346-350Abstract
Batch sorption experiments were carried out using a novel adsorbent, Acid treated Pongamia Leaf Powder (APLP) and Acid treated Neem Leaf Powder (ANLP), for the removal of Chromium(VI) from aqueous solutions. Potential of APLP and ANLP for adsorption of chromium from aqueous solution was found to be excellent. Effects of process parameters pH, contact time and adsorbent capacity were studied. Langmuir model represent the experimental data well. Maximum dye uptake was found indicating that APLP and ANLP can be used as an excellent low-cost adsorbent. Comparison of adsorption capacity of APLP and ANLP for chromium clearly indicates that the capacity of APLP for adsorption of chromium is quite high than ANLP. It can be expected that APLP and ANLP would have similar capacities for dyes with similar molecular weight, structure and/or ionic load. Thus, the naturally defoliated the Pongamia and Neem leaf powders a low-cost natural resource, can be effectively used to remove pollutants from effluents.- Molecular Interaction Studies of Phosphatidylcholine As Drug Delivery Substrate For Asenapine Maleate
Abstract Views :231 |
PDF Views:83
Authors
A. Harani
1,
J. VijayaRatnam
1,
B. Dipankar
2,
D. Sathis Kumar
3,
M. Bhagya Lalitha
3,
S. P. N. Kumar
3
Affiliations
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, IN
2 Certum Analytics, Certum Ventures Private Limited, Hyderabad - 500 023, IN
3 Aditya Pharmacy College, Surampalem - 533 437, IN
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, IN
2 Certum Analytics, Certum Ventures Private Limited, Hyderabad - 500 023, IN
3 Aditya Pharmacy College, Surampalem - 533 437, IN
Source
Current Science, Vol 115, No 3 (2018), Pagination: 499-504Abstract
Phospholipid complexes have become promising delivery systems for delivery of drugs with poor bioavailability like asenapine maleate. To improve the bioavailability of asenapine maleate, phospholipid complex was chosen for the drug with Phospholipon 90 G (phosphatidylcholine). The automated molecular docking calculation for asenapine and maleate individually with phospholipid was performed by AutoGrid 4.2.6, a docking program. The van der Waals hydrogen bond, electrostatic potential energy and desolvation free energy grid maps were calculated by AutoDock parameter set- and distance-dependent dielectric functions respectively. The change in free energy was specifically seen for the complex between asenapine and phospholipid which exhibited least binding docking energy of –3.86 kcal/mol among the summary of 25 poses. Finally, molecular docking studies confirmed that the asenapine is able to make a complex with phosphatidylcholine, plausibly on account of its structural similarity with phospholipid in its physiochemical properties.Keywords
Asenapine, Binding Docking Energy, Maleate, Phosphatidylcholine.Full Text
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